Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729-0292, Japan.
Molecules. 2019 Apr 7;24(7):1366. doi: 10.3390/molecules24071366.
Many studies have demonstrated that oxidative stress plays an important role in several ailments including neurodegenerative diseases and cerebral ischemic injury. Previously we synthesized some carbazole compounds that have anti-oxidant ability in vitro. In this present study, we found that one of these 22 carbazole compounds, compound (3-ethoxy-1-hydroxy-8- methoxy-2-methylcarbazole-5-carbaldehyde), had the ability to protect neuro2a cells from hydrogen peroxide-induced cell death. It is well known that neurite loss is one of the cardinal features of neuronal injury. Our present study revealed that compound had the ability to induce neurite outgrowth through the PI3K/Akt signaling pathway in neuro2a cells. These findings suggest that compound might exert a neurotrophic effect and thus be a useful therapy for the treatment of brain injury.
许多研究表明，氧化应激在多种疾病中起着重要作用，包括神经退行性疾病和脑缺血损伤。我们之前合成了一些具有体外抗氧化能力的咔唑类化合物。在本研究中，我们发现这些咔唑类化合物中的一种，化合物（3-乙氧基-1-羟基-8-甲氧基-2-甲基咔唑-5-甲酰），具有保护神经细胞免受过氧化氢诱导的细胞死亡的能力。众所周知，轴突损失是神经元损伤的主要特征之一。我们的研究表明，化合物通过神经细胞中的 PI3K/Akt 信号通路诱导轴突生长。这些发现表明，化合物可能发挥神经营养作用，因此可能是治疗脑损伤的一种有用疗法。
