Ogburn P L, Williams P P, Johnson S B, Holman R T
Am J Obstet Gynecol. 1984 Jan 1;148(1):5-9. doi: 10.1016/s0002-9378(84)80023-x.
Fifteen serum samples from 11 women with preeclampsia and 19 samples from 10 normal third-trimester pregnancies were analyzed for total nonesterified fatty acids and total nonesterified arachidonic acid. The percentages of arachidonic acid in nonesterified fatty acids, in phospholipids, in triglycerides, and in cholesterol esters were also measured in each sample. The same analyses were done on serum from six samples of cord blood from each group. Cord blood sera from preeclamptic and normal pregnancies had much less total nonesterified fatty acids than the corresponding maternal sera but had much higher percentages of arachidonic acid in each of the major lipid categories. The maternal phospholipids and cholesterol esters had higher proportions of arachidonic acid in preeclampsia than in normal pregnancy. Samples from placentas of preeclamptic pregnancies had significantly lower proportions of arachidonic acid in the nonesterified fatty acids and triglycerides than normal placentas. These findings suggest a decreased availability of arachidonic acid in the fetal circulation which may result in decreased production of prostacyclin in preeclampsia.
对11名先兆子痫女性的15份血清样本以及10名孕晚期正常孕妇的19份样本进行了总游离脂肪酸和总游离花生四烯酸分析。还测定了每份样本中游离脂肪酸、磷脂、甘油三酯和胆固醇酯中花生四烯酸的百分比。对每组6份脐血样本的血清进行了同样的分析。先兆子痫孕妇和正常孕妇的脐血血清中总游离脂肪酸比相应的母体血清少得多，但在每种主要脂质类别中花生四烯酸的百分比要高得多。先兆子痫孕妇的母体磷脂和胆固醇酯中花生四烯酸的比例高于正常妊娠。先兆子痫孕妇胎盘样本中游离脂肪酸和甘油三酯中花生四烯酸的比例明显低于正常胎盘。这些发现表明胎儿循环中花生四烯酸的可用性降低，这可能导致先兆子痫中前列环素的产生减少。
