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通过与从生物变种TA-1中分离出的环索糖络合提高阿特拉津的溶解度

Solubility Enhancement of Atrazine by Complexation with Cyclosophoraose Isolated from biovar TA-1.

作者信息

Kim Yohan, Shinde Vijay Vilas, Jeong Daham, Choi Youngjin, Jung Seunho

机构信息

Department of Systems Biotechnology & Dept. of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, Korea.

Institute for Ubiquitous Information Technology and Applications (UBITA), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, Korea.

出版信息

Polymers (Basel). 2019 Mar 12;11(3):474. doi: 10.3390/polym11030474.

DOI:10.3390/polym11030474
PMID:30960458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6473739/
Abstract

biovar TA-1, a kind of soil bacteria, produces cyclosophoraoses (Cys). Cyclosophoraoses contain various ring sizes with degrees of polymerization ranging from 17 to 23. Atrazine is a hardly-soluble herbicide that contaminates soil and drinking water, and remains in soil for a long time. To remove this insoluble contaminant from aqueous solutions, we have enhanced the solubility of atrazine by complexation with Cys. The complex formation of Cys and atrazine was confirmed using ¹H nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), field emission scanning electron microscopy (FE-SEM), rotating frame nuclear overhauser spectroscopy (ROESY), and molecular modeling studies. The aqueous solubility of atrazine was enhanced 3.69-fold according to the added concentrations (20 mM) of Cys, compared to the 1.78-fold enhancements by β-cyclodextrin (β-CD). Cyclosophoraoses as an excellent solubility enhancer with long glucose chains that can effectively capture insoluble materials showed a potential application of microbial polysaccharides in the removal of hazardous hardly-soluble materials from aqueous solutions in the fields of biological and environmental industry.

摘要

生物变种TA-1是一种土壤细菌，可产生环索糖（Cys）。环索糖含有各种不同大小的环，聚合度范围为17至23。阿特拉津是一种难溶性除草剂，会污染土壤和饮用水，并在土壤中长时间残留。为了从水溶液中去除这种不溶性污染物，我们通过与环索糖形成络合物提高了阿特拉津的溶解度。使用¹H核磁共振（NMR）、傅里叶变换红外（FT-IR）光谱、差示扫描量热法（DSC）、场发射扫描电子显微镜（FE-SEM）、旋转框架核Overhauser光谱（ROESY）和分子模拟研究证实了环索糖与阿特拉津的络合物形成。与β-环糊精（β-CD）使阿特拉津溶解度提高1.78倍相比，根据环索糖的添加浓度（20 mM），阿特拉津的水溶性提高了3.69倍。环索糖作为一种具有长葡萄糖链的优异增溶剂，能够有效捕获不溶性物质，显示出微生物多糖在生物和环境工业领域从水溶液中去除有害难溶性物质方面的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/28ac0f3f30c3/polymers-11-00474-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/919525ed25bd/polymers-11-00474-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/54740a53cf0e/polymers-11-00474-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/7d52e5815a66/polymers-11-00474-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/1d28063b2ca2/polymers-11-00474-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/c2b7a414f6a1/polymers-11-00474-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/c3c6006d7b5f/polymers-11-00474-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/bfc75f93669d/polymers-11-00474-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/29d74002937b/polymers-11-00474-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/28ac0f3f30c3/polymers-11-00474-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/919525ed25bd/polymers-11-00474-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/54740a53cf0e/polymers-11-00474-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/7d52e5815a66/polymers-11-00474-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/1d28063b2ca2/polymers-11-00474-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/c2b7a414f6a1/polymers-11-00474-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/c3c6006d7b5f/polymers-11-00474-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/bfc75f93669d/polymers-11-00474-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/29d74002937b/polymers-11-00474-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0302/6473739/28ac0f3f30c3/polymers-11-00474-g009.jpg

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