Sharma Aruna, Muresanu Dafin F, Ozkizilcik Asya, Tian Z Ryan, Lafuente José Vicente, Manzhulo Igor, Mössler Herbert, Sharma Hari Shanker
International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Department of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania; "RoNeuro" Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
Prog Brain Res. 2019;245:1-55. doi: 10.1016/bs.pbr.2019.03.002. Epub 2019 Apr 2.
Sleep deprivation (SD) is very common in military personnel resulting in mental anomalies and interfering with decision-making capabilities. Moreover during combat operation, these sleep-deprived soldiers often receive blunt head trauma casing concussive head injury (CHI). Recent observations clearly suggest that SD alone induces brain pathology and additional CHI further exacerbates brain damage. Thus, the need of the hour is to explore possible effective therapeutic measures to induce neuroprotection to enhance quality of life of these military personnel. This review deals with novel aspects of treatment using nanotechnology to induce superior neuroprotection following CHI in SD based on our own investigation in the light of recent literature in the field.
睡眠剥夺（SD）在军事人员中非常普遍，会导致精神异常并干扰决策能力。此外，在战斗行动中，这些睡眠不足的士兵经常遭受钝性头部创伤，导致脑震荡性头部损伤（CHI）。最近的观察清楚地表明，单独的睡眠剥夺会诱发脑部病变，而额外的脑震荡性头部损伤会进一步加剧脑损伤。因此，当务之急是探索可能有效的治疗措施，以诱导神经保护，提高这些军事人员的生活质量。本综述基于我们自己的研究，并结合该领域的最新文献，探讨了利用纳米技术在睡眠剥夺后的脑震荡性头部损伤后诱导卓越神经保护的治疗新方法。
