Lazarchick J, Stubbs T M, Romein L A
Ann Clin Lab Sci. 1986 Sep-Oct;16(5):395-8.
It has been suggested that the basis for the marked discordance in factor VIII parameters in preeclampsia is the result of proteolysis of the factor VIII procoagulant component (VIII:C) owing to activation of the coagulation system. To investigate this further, levels were compared of factor VIII:C and VIII:C (Ag), the immunologic equivalent of the procoagulant activity, in a series of preeclamptic patients and patients with uncomplicated pregnancies. No significant difference in the mean (+/- SD) level of factor VIII:C or VIII:C (Ag) could be detected between these groups. Our results do not support proteolysis of factor VIII:C as a mechanism to account for the discordant levels of the factor VIII parameters in preeclampsia.
有人提出，子痫前期中因子VIII参数显著不一致的基础是由于凝血系统激活导致因子VIII促凝成分（VIII:C）发生蛋白水解。为了进一步研究这一点，对一系列子痫前期患者和正常妊娠患者的因子VIII:C和VIII:C（Ag，促凝活性的免疫学等效物）水平进行了比较。在这些组之间未检测到因子VIII:C或VIII:C（Ag）的平均（±标准差）水平有显著差异。我们的结果不支持因子VIII:C蛋白水解作为子痫前期中因子VIII参数水平不一致的机制。
