Ogawa T, Suzuki Y, Sayama S, Soma H
Biol Res Pregnancy Perinatol. 1983;4(4):155-7.
The ratios of Factor VIII-related antigen (FVIIIR:Ag) to Factor VIII clotting activity (FVIIIC) were measured in 50 women during normal pregnancy and in 20 patients with preeclampsia and with intrauterine fetal growth retardation (IUGR). The mean ratios of FVIIIR:Ag to FVIIIC ranged from 0.6 +/- 0.22 to 0.8 +/- 0.58 (mean +/- SD) from the 28th to 40th week of normal pregnancy. On the other hand, the mean ratios of FVIIIR:Ag to FVIIIC in patients with preeclampsia and IUGR were 1.40 +/- 0.69 and 1.59 +/- 0.78 (mean +/- SD), respectively. This finding suggests that FVIII complex ratio may be considered an index of endothelial damage in preeclampsia and IUGR. This ratio test could be a more sensitive and reliable indicator of placental insufficiency if applied with non-stress test during late pregnancy.
对50名正常妊娠女性以及20名先兆子痫和宫内胎儿生长受限（IUGR）患者测定了因子VIII相关抗原（FVIIIR:Ag）与因子VIII凝血活性（FVIIIC）的比值。正常妊娠第28至40周，FVIIIR:Ag与FVIIIC的平均比值范围为0.6±0.22至0.8±0.58（平均值±标准差）。另一方面，先兆子痫和IUGR患者中FVIIIR:Ag与FVIIIC的平均比值分别为1.40±0.69和1.59±0.78（平均值±标准差）。这一发现表明，FVIII复合物比值可能被视为先兆子痫和IUGR中内皮损伤的一个指标。如果在妊娠晚期与无应激试验一起应用，该比值检测可能是胎盘功能不全更敏感和可靠的指标。
