Enyedi P, Mucsi I, Hunyady L, Catt K J, Spät A
Biochem Biophys Res Commun. 1986 Nov 14;140(3):941-7. doi: 10.1016/0006-291x(86)90726-6.
A non-hydrolysable GTP analogue enhanced the formation of [3H]inositol polyphosphates in permeabilized adrenal glomerulosa cells. Pertussis toxin, which ADP-ribosylated Ni, failed to influence angiotensin-induced formation of 3H-labelled inositol phosphates and the incorporation of [32F]phosphate into phosphatidylinositol and phosphatidic acid. These results show that Ni is present and a G-protein activates phospholipase C also in glomerulosa cells, however, it is not Ni which couples angiotensin receptors to the enzyme.
一种不可水解的GTP类似物增强了透化肾上腺球状带细胞中[3H]肌醇多磷酸的形成。百日咳毒素可使Ni进行ADP核糖基化，但未能影响血管紧张素诱导的3H标记肌醇磷酸的形成以及[32F]磷酸盐掺入磷脂酰肌醇和磷脂酸。这些结果表明，肾上腺球状带细胞中存在Ni，且一种G蛋白也可激活磷脂酶C，然而，将血管紧张素受体与该酶偶联的并非Ni。
