Garotta G, Talmadge K W, Pink J R, Dewald B, Baggiolini M
Biochem Biophys Res Commun. 1986 Nov 14;140(3):948-54. doi: 10.1016/0006-291x(86)90727-8.
A three-day treatment with IFN-gamma enhanced up to 300% the capacity of human monocytes and macrophages to produce H2O2 during the respiratory burst. IFN-alpha or -beta (type I IFNs), which did not by themselves influence the burst, were found to antagonize the enhancing effect of IFN-gamma (type II IFN). The antagonism was concentration-dependent and required the presence of type I IFNs during the whole period of IFN-gamma pretreatment. These results suggest that the host defense function of mononuclear phagocytes may be controlled by the relative local concentrations of type I and type II IFNs.
用γ干扰素进行为期三天的治疗，可使人类单核细胞和巨噬细胞在呼吸爆发期间产生过氧化氢的能力增强高达300%。发现α干扰素或β干扰素（I型干扰素）本身虽不影响呼吸爆发，但能拮抗γ干扰素（II型干扰素）的增强作用。这种拮抗作用呈浓度依赖性，并且在γ干扰素预处理的整个期间都需要有I型干扰素存在。这些结果表明，单核吞噬细胞的宿主防御功能可能受I型和II型干扰素相对局部浓度的控制。
