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黄连：传统用途、植物学、植物化学、药理学和毒理学的综合评价。

Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology.

机构信息

a College of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , China.

b Ya'an Xun Kang Pharmaceutical Co., Ltd , Ya'an , China.

出版信息

Pharm Biol. 2019 Dec;57(1):193-225. doi: 10.1080/13880209.2019.1577466.

DOI:10.1080/13880209.2019.1577466
PMID:30963783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6461078/
Abstract

CONTEXT: Coptidis rhizome (CR), also known as Huanglian in Chinese, is the rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teeta Wall (Ranunculaceae). It has been widely used to treat bacillary dysentery, diabetes, pertussis, sore throat, aphtha, and eczema in China. OBJECTIVES: The present paper reviews the latest advances of CR, focusing on the botany, phytochemistry, traditional usages, pharmacokinetics, pharmacology and toxicology of CR and its future perspectives. METHODS: Studies from 1985 to 2018 were reviewed from books; PhD. and MSc. dissertations; the state and local drug standards; PubMed; CNKI; Scopus; the Web of Science; and Google Scholar using the keywords Coptis, Coptidis Rhizoma, Huanglian, and goldthread. RESULTS: Currently, 128 chemical constituents have been isolated and identified from CR. Alkaloids are the characteristic components, together with organic acids, coumarins, phenylpropanoids and quinones. The extracts/compounds isolated from CR cover a wide pharmacological spectrum, including antibacterial, antivirus, antifungal, antidiabetic, anticancer and cardioprotective effects. Berberine is the most important active constituent and the primary toxic component of CR. CONCLUSIONS: As an important herbal medicine in Chinese medicine, CR has the potential to treat various diseases. However, further research should be undertaken to investigate the clinical effects, toxic constituents, target organs and pharmacokinetics, and to establish criteria for quality control, for CR and its related medications. In addition, the active constituents, other than alkaloids, in both raw and processed products of CR should be investigated.

摘要

背景：黄连，又称黄连，是毛茛科黄连属植物黄连、三角黄连或黄连的根茎。在中国，黄连被广泛用于治疗细菌性痢疾、糖尿病、百日咳、咽喉痛、口疮和湿疹。

目的：本文综述了黄连的最新研究进展，重点介绍了黄连的植物学、植物化学、传统用途、药代动力学、药理学和毒理学及其未来展望。

方法：从书籍、博士和硕士论文、国家和地方药品标准、PubMed、CNKI、Scopus、Web of Science 和 Google Scholar 中检索了 1985 年至 2018 年的研究，使用的关键词有黄连、黄连、黄连和黄连。

结果：目前已从黄连中分离鉴定出 128 种化学成分。生物碱是其特征成分，还有有机酸、香豆素、苯丙素和醌类。从黄连中分离得到的提取物/化合物具有广泛的药理作用，包括抗菌、抗病毒、抗真菌、抗糖尿病、抗癌和心脏保护作用。小檗碱是黄连最重要的活性成分和主要毒性成分。

结论：黄连作为中药的重要药材，具有治疗多种疾病的潜力。然而，还需要进一步研究黄连及其相关药物的临床疗效、毒性成分、靶器官和药代动力学，建立质量控制标准。此外，还应研究黄连生品和炮制品中除生物碱以外的其他活性成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/a1956a04a290/IPHB_A_1577466_F0010_B.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/a1956a04a290/IPHB_A_1577466_F0010_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/000274b9c765/IPHB_A_1577466_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/7920f2be2e13/IPHB_A_1577466_F0002_B.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/4c8f0252db34/IPHB_A_1577466_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/f6981bbed9e3/IPHB_A_1577466_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/da7f7e41d377/IPHB_A_1577466_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/3f08b854e880/IPHB_A_1577466_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/c4fc4201df1e/IPHB_A_1577466_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/e6a743d31614/IPHB_A_1577466_F0009_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c0b/6461078/a1956a04a290/IPHB_A_1577466_F0010_B.jpg

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本文引用的文献

[1]
Coptisine suppresses tumor growth and progression by down-regulating MFG-E8 in colorectal cancer.

RSC Adv. 2018-9-3

[2]
Coptisine Induces Apoptosis in Human Hepatoma Cells Through Activating 67-kDa Laminin Receptor/cGMP Signaling.

Front Pharmacol. 2018-5-18

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Anti-hypercholesterolemic Effect of Berbamine Isolated from in Hypercholesterolemic Zebrafish Induced by High-Cholesterol Diet.

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Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.

Biomed Pharmacother. 2018-4-25

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Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1.

Cancer Lett. 2018-4-10

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Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation.

Aging Dis. 2017-12-1

[7]
Excessive Autophagy Activation and Increased Apoptosis Are Associated with Palmitic Acid-Induced Cardiomyocyte Insulin Resistance.

J Diabetes Res. 2017-11-26

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Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7.

Mol Cell Probes. 2017-12-24

[9]
Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1.

Sci Rep. 2017-11-14

[10]
Impacts of berberine on oxidized LDL-induced proliferation of human umbilical vein endothelial cells.

Am J Transl Res. 2017-10-15

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