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脂肪组织激活移植治疗外伤性脊髓损伤后的神经保护、功能恢复和内源性神经发生。

Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue.

机构信息

Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Via A. di Rudinì 8, 20142 Milan, Italy.

Pediatric Clinical Research Center "Fondazione Romeo e Enrica Invernizzi", University of Milan, via Giovanni Battista Grassi 74, 20142 Milan, Italy.

出版信息

Cells. 2019 Apr 8;8(4):329. doi: 10.3390/cells8040329.

DOI:10.3390/cells8040329
PMID:30965679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6523261/
Abstract

Spinal cord injury (SCI) is a devastating disease, which leads to paralysis and is associated to substantially high costs for the individual and society. At present, no effective therapies are available. Here, the use of mechanically-activated lipoaspirate adipose tissue (MALS) in a murine experimental model of SCI is presented. Our results show that, following acute intraspinal MALS transplantation, there is an engraftment at injury site with the acute powerful inhibition of the posttraumatic inflammatory response, followed by a significant progressive improvement in recovery of function. This is accompanied by spinal cord tissue preservation at the lesion site with the promotion of endogenous neurogenesis as indicated by the significant increase of Nestin-positive cells in perilesional areas. Cells originated from MALS infiltrate profoundly the recipient cord, while the extra-dural fat transplant is gradually impoverished in stromal cells. Altogether, these novel results suggest the potential of MALS application in the promotion of recovery in SCI.

摘要

脊髓损伤（SCI）是一种毁灭性的疾病，会导致瘫痪，并给个人和社会带来巨大的经济负担。目前，尚无有效的治疗方法。在这里，我们提出了在 SCI 的小鼠实验模型中使用机械激活脂肪抽吸脂肪组织（MALS）的方法。我们的研究结果表明，在急性脊髓内 MALS 移植后，会在损伤部位有移植物的植入，急性强烈抑制创伤后的炎症反应，随后功能恢复显著改善。这伴随着损伤部位脊髓组织的保留，并促进内源性神经发生，表现为损伤周围区域巢蛋白阳性细胞的显著增加。源自 MALS 的细胞深入浸润到受者的脊髓中，而硬膜外脂肪移植中的基质细胞则逐渐减少。总之，这些新的结果表明 MALS 应用于促进 SCI 恢复的潜力。

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