Song Jian, Liao Zhenhua, Shi Hongyu, Xiang Dingding, Xu Lin, Liu Yuhong, Mu Xiaohong, Liu Weiqiang
State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China.
Biomechanics and Biotechnology Lab, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China.
Polymers (Basel). 2017 Nov 10;9(11):589. doi: 10.3390/polym9110589.
Titanium (Ti) and its alloys are widely used in biomedical devices. As biomaterials, the blood compatibility of Ti and its alloys is important and needs to be further improved to provide better functionality. In this work, we studied the suitability of zirconia (ZrO₂) particle reinforced poly-ether-ether-ketone (PEEK) coatings on Ti6Al4V substrates for blood-contacting implants. The wettability, surface roughness and elastic modulus of the coatings were examined. Blood compatibility tests were conducted by erythrocytes observation, hemolysis assay and clotting time of recalcified human plasma, to find out correlations between the microstructure of the ZrO₂-filled PEEK composite coatings and their blood compatibilities. The results suggested that adding ZrO₂ nanoparticles increased the surface roughness and improved the wettability and Derjaguin-Muller-Toporov (DMT) elastic modulus of PEEK coating. The PEEK composite matrix coated Ti6Al4V specimens did not cause any aggregation of erythrocytes, showing morphological normal shapes. The hemolysis rate (HR) values of the tested specimens were much less than 5% according to ISO 10993-4 standard. The values of plasma recalcification time (PRT) of the tested specimens varied with the increasing amount of ZrO₂ nanoparticles. Based on the results obtained, 10 wt % ZrO₂ particle reinforced PEEK coating has demonstrated an optimum blood compatibility, and can be considered as a candidate to improve the performance of existing PEEK based coatings on titanium substrates.
钛（Ti）及其合金广泛应用于生物医学设备。作为生物材料，Ti及其合金的血液相容性很重要，需要进一步改善以提供更好的功能。在这项工作中，我们研究了氧化锆（ZrO₂）颗粒增强聚醚醚酮（PEEK）涂层在Ti6Al4V基体上用于血液接触植入物的适用性。检测了涂层的润湿性、表面粗糙度和弹性模量。通过红细胞观察、溶血试验和复钙人血浆的凝血时间进行血液相容性测试，以找出ZrO₂填充的PEEK复合涂层的微观结构与其血液相容性之间的相关性。结果表明，添加ZrO₂纳米颗粒增加了表面粗糙度，改善了PEEK涂层的润湿性和德亚金-穆勒-托波罗夫（DMT）弹性模量。涂覆有PEEK复合基体的Ti6Al4V试样未引起任何红细胞聚集，显示出形态正常的形状。根据ISO 10993-4标准，测试试样的溶血率（HR）值远低于5%。测试试样的血浆复钙时间（PRT）值随ZrO₂纳米颗粒含量的增加而变化。基于所得结果，10 wt%ZrO₂颗粒增强的PEEK涂层已显示出最佳的血液相容性，可被视为改善钛基体上现有PEEK基涂层性能的候选材料。
