Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
J Mech Behav Biomed Mater. 2021 Aug;120:104541. doi: 10.1016/j.jmbbm.2021.104541. Epub 2021 May 19.
Poly-ether-ether-ketone (PEEK) has been the promising implantation material since it was first applied in the medical field in the 1990s. With its irreplaceable advantages, such as high mechanical and biological properties, human-like tensile strength and elastic modulus, and excellent physical and chemical stability, PEEK has been regarded as an excellent implantation material, and has been widely used in orthopedics, reconstructive surgery, and dentistry. However, PEEK also has an obvious shortcoming of poor bone compatibility due to its inherent hydrophobicity and bio-inertia, which is a great challenge for its prospect. In the present study, based on the acknowledged fact that enhancing the roughness of PEEK can improve its bone compatibility, modified porous PEEK implants with different porosities (40%, 50%, 60% and solid) were fabricated by Fused Deposition Modeling (FDM), and experiments in vitro and in vivo were conducted to determine whether the bone compatibility can be improved, and compare the biological properties between different porosities. These results indicate that both in vitro and in vivo, the bone compatibility of the modified porous PEEK has been strongly improved, when compared to the control group (solid PEEK implants). In vitro and in vivo, the 40%-porosity-PEEK possessed the highest bone compatibility.
聚醚醚酮（PEEK）自 20 世纪 90 年代首次应用于医学领域以来，一直是很有前途的植入材料。由于其具有不可替代的优势，如高机械性能和生物性能、与人相似的拉伸强度和弹性模量、以及优异的物理和化学稳定性，PEEK 已被视为一种优良的植入材料，广泛应用于骨科、重建外科和牙科。然而，PEEK 也存在固有疏水性和生物惰性导致的明显缺点，即骨相容性差，这对其前景是一个巨大的挑战。在本研究中，基于公认的事实，即提高 PEEK 的粗糙度可以改善其骨相容性，我们通过熔融沉积建模（FDM）制造了具有不同孔隙率（40%、50%、60%和实心）的改性多孔 PEEK 植入物，并进行了体外和体内实验，以确定是否可以改善骨相容性，并比较不同孔隙率之间的生物学特性。这些结果表明，与对照组（实心 PEEK 植入物）相比，改性多孔 PEEK 的体外和体内骨相容性均得到了显著改善。体外和体内实验中，40%孔隙率-PEEK 具有最高的骨相容性。
