Syed G B, Sharma D B, Raina R K
Dev Pharmacol Ther. 1986;9(5):317-22. doi: 10.1159/000457110.
Phenobarbitone kinetics was studied in malnourished and normal children after single oral dose of approximately 7.0 mg/kg. Estimation of serum phenobarbitone concentration was performed by spectrophotometric method. Elimination half-life was 58.9 +/- 9.5 h and 30.15 +/- 6.1 h for malnourished and healthy children, respectively. Compared to healthy children, tmax was prolonged in malnutrition group suggesting slow absorption in the latter group. The systemic bioavailability was observed to be higher in protein energy malnutrition. Modifications of the usual dosage regimen in malnutrition are recommended.
在单次口服约7.0毫克/千克剂量后，对营养不良儿童和正常儿童的苯巴比妥动力学进行了研究。采用分光光度法测定血清苯巴比妥浓度。营养不良儿童和健康儿童的消除半衰期分别为58.9±9.5小时和30.15±6.1小时。与健康儿童相比，营养不良组的达峰时间延长，表明该组吸收缓慢。观察到蛋白质能量营养不良时全身生物利用度较高。建议对营养不良时的常规给药方案进行调整。
