Bano G, Raina R K, Sharma D B
Pharmacology. 1986;32(4):232-6. doi: 10.1159/000138174.
The pharmacokinetics of carbamazepine was studied in 6 children with protein energy malnutrition (PEM) and in 6 healthy children. Plasma carbamazepine was estimated by enzyme multiplied immunoassay technique. Single-dose concentration profiles after 10 mg/kg of the drug showed lower plasma peak levels. The systemic availability (AUC 0-48 h) of the drug in PEM was also reduced. Based on these observations, suggestions have been made for rescheduling the dosage of the drug in PEM.
在6名蛋白质能量营养不良（PEM）儿童和6名健康儿童中研究了卡马西平的药代动力学。采用酶放大免疫分析技术测定血浆卡马西平浓度。给予10mg/kg药物后的单剂量浓度曲线显示血浆峰值水平较低。PEM患儿中该药物的全身可用性（AUC 0 - 48小时）也降低。基于这些观察结果，已就重新调整PEM患儿的药物剂量提出了建议。
