Dmowski W P, Radwanska E, Binor Z, Rana N
Fertil Steril. 1986 Nov;46(5):784-9. doi: 10.1016/s0015-0282(16)49811-0.
The effectiveness of ovulation induction with clomiphene citrate or human menopausal gonadotropins was evaluated in 52 infertile women with stage I or stage II endometriosis and ovulatory dysfunction: anovulation or luteinized unruptured follicle (LUF) syndrome before (group I) and after (group II) danazol treatment. The incidence of anovulation and LUF in the endometriosis population was 9% and 34%, respectively. In group I, 10 of 36 patients (27.8%) conceived, with an average of 17.6 induction cycles per pregnancy. In group II, 21 of 30 patients (70%) conceived, with an average of 4.5 cycles per pregnancy (difference significant at P less than 0.001). There was no difference in the average number of ovulation induction cycles per patient between groups I and II (4.9 and 3.1, respectively). Of 14 patients who did not conceive in group I and crossed over to group II, 9 (64.3%) conceived (not different from group II). Spontaneous abortion rates were 20% in group I and 14% in group II. These results indicate that mild endometriosis may interfere with conception through mechanisms other than ovulatory dysfunction and that treatment with danazol appears to more than double the fertility rate.
对52例患有I期或II期子宫内膜异位症且排卵功能障碍（无排卵或黄素化未破裂卵泡综合征）的不孕女性，评估了枸橼酸氯米芬或人绝经期促性腺激素诱导排卵的有效性：分别在达那唑治疗前（I组）和治疗后（II组）进行评估。子宫内膜异位症患者中无排卵和黄素化未破裂卵泡综合征的发生率分别为9%和34%。I组36例患者中有10例（27.8%）受孕，每次妊娠平均诱导排卵周期数为17.6个。II组30例患者中有21例（70%）受孕，每次妊娠平均周期数为4.5个（P<0.001时差异有统计学意义）。I组和II组每位患者的平均诱导排卵周期数无差异（分别为4.9个和3.1个）。I组中14例未受孕且转入II组的患者中，有9例（64.3%）受孕（与II组无差异）。I组和II组的自然流产率分别为20%和14%。这些结果表明，轻度子宫内膜异位症可能通过排卵功能障碍以外的机制干扰受孕，且达那唑治疗似乎使生育率提高了一倍多。
