Greenblatt R B, Tzingounis V
Fertil Steril. 1979 Nov;32(5):518-20. doi: 10.1016/s0015-0282(16)44350-5.
Forty-nine women diagnosed as having pelvic endometriosis were treated with 800 mg of danazol/day for a mean duration of 6 months. The average length of the follow-up period was 78 months. Side effects were minimal, and regular ovulatory menses returned within 25 to 90 days (average 42 days). Forty-two (85.7% of these women had associated infertility. Recurrence of symptoms was reported in 33% but in no patient were the symptoms worse than before entering the study. Of 30 patients desirous of pregnancy, 20 were potentially fertile; of these, 10 conceived within 6 months of discontinuing therapy, for a conception rate of 50%. Nine of the remaining ten patients required additional therapeutic procedures (surgery and/or danazol), and four of these conceived within 12 months. These results compare favorably with those of other investigations, since most of our patients were referred to us after being subjected to a variety of regimens, both hormonal and surgical.
四十九名被诊断患有盆腔子宫内膜异位症的女性接受了每日800毫克达那唑的治疗，平均疗程为6个月。随访期的平均时长为78个月。副作用极小，规律的排卵性月经在25至90天内恢复（平均42天）。其中四十二名（85.7%）女性伴有不孕症。有33%的患者报告症状复发，但没有一名患者的症状比进入研究前更严重。在30名渴望怀孕的患者中，20名具有潜在生育能力；其中，10名在停止治疗后的6个月内受孕，受孕率为50%。其余十名患者中有九名需要额外的治疗程序（手术和/或达那唑），其中四名在12个月内受孕。这些结果与其他研究结果相比更具优势，因为我们的大多数患者在接受了各种激素和手术治疗方案后才被转诊至我们这里。
