Djursing H, Hagen C, Andersen A N, Nyholm H C, Petersen K
Fertil Steril. 1986 Nov;46(5):840-5.
Patients with functional amenorrhea may have a raised central dopaminergic activity, leading to inhibition of pituitary-ovarian function. In a double-blind placebo trial, ten patients with amenorrhea received metoclopramide (MTC) orally in daily doses from 20 to 7.5 mg in a sequential form for 10 weeks. Six patients received placebo. Serum levels for luteinizing hormone (P less than 0.02), follicle-stimulating hormone (P less than 0.05), and prolactin (P less than 0.001) increased significantly during MTC administration, and no (P greater than 0.05) hormonal changes occurred in the placebo group. Six patients observed vaginal bleedings during MTC administration but without postovulatory progesterone levels. Dopamine receptor blockade may activate the hypothalamic-pituitary axis of amenorrheic patients, although an ovulatory response is not achieved.
功能性闭经患者可能存在中枢多巴胺能活性升高，导致垂体 - 卵巢功能受到抑制。在一项双盲安慰剂试验中，10例闭经患者以序贯形式口服甲氧氯普胺（MTC），日剂量从20 mg至7.5 mg，持续10周。6例患者接受安慰剂治疗。在服用MTC期间，促黄体生成素（P<0.02）、促卵泡生成素（P<0.05）和催乳素（P<0.001）的血清水平显著升高，而安慰剂组未出现（P>0.05）激素变化。6例患者在服用MTC期间出现阴道出血，但无排卵后孕酮水平。多巴胺受体阻断可能激活闭经患者的下丘脑 - 垂体轴，尽管未实现排卵反应。
