Potin V V, Isakov A V, Svechnikova F A
Probl Endokrinol (Mosk). 1989 Mar-Apr;35(2):44-8.
The levels of FSN, LH, prolactin, estradiol, and progesterone were investigated in the blood of 26 women with hypothalamic amenorrhea (in 17 of them it resulted from body mass deficiency) before and during metoclopramide therapy (the drug was administered at a daily dose of 20 mg for 1 = 9 mos). The administration of the drug per os in 3 h resulted in a considerable rise of the blood level of prolactin in patients with body mass deficiency. Regular administration of the drug in this group normalized the anovulatory cycle in 5 women and caused pregnancy in one woman. In the authors opinion, this effect was due to a decrease in dopaminergic inhibition of the anterior pituitary lobe and the restoration of the mechanism of positive feedback between the ovaries and pituitary gland.
对26名下丘脑性闭经女性（其中17名因体重不足所致）在胃复安治疗前及治疗期间（药物每日剂量20mg，给药1-9个月）的血液中促卵泡生成素（FSN）、促黄体生成素（LH）、催乳素、雌二醇和孕酮水平进行了研究。对体重不足的患者口服该药3小时后，催乳素的血液水平显著升高。该组患者定期给药使5名女性的无排卵周期恢复正常，1名女性怀孕。作者认为，这种作用是由于垂体前叶多巴胺能抑制作用减弱以及卵巢与垂体之间正反馈机制恢复所致。
