唾液腺黏液表皮样癌中的凋亡信号。

Apoptotic signaling in salivary mucoepidermoid carcinoma.

机构信息

International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.

Department of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, São Paulo, Brazil.

出版信息

Head Neck. 2019 Sep;41(9):2904-2913. doi: 10.1002/hed.25763. Epub 2019 Apr 9.

DOI:10.1002/hed.25763

PMID:30968512

Abstract

BACKGROUND

Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions.

METHODS

The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases.

RESULTS

Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates.

CONCLUSIONS

The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma.

摘要

背景

黏液表皮样癌是最常见的涎腺恶性肿瘤。细胞凋亡在腺体结构的发生中起着重要作用，凋亡机制的异常与广泛的病理状况有关。

方法

评估了 40 例黏液表皮样癌中与凋亡和增殖相关的蛋白的免疫表达。

结果

Par-4、Survivin、MUC1、PHLDA1、Fas 和 Ki-67 在黏液表皮样癌中主要表达。FasL 表达很少，几乎 50%的病例中观察到 Caspase-3 表达。SPARC 的表达与低级别肿瘤相关，Ki-67 的表达与淋巴结转移相关。Fas 的表达和 Ki-67 及 Caspase-3 的表达降低与更好的总癌症特异性生存率相关。