[转化生长因子-β(1)和Ki-67核抗原在涎腺黏液表皮样癌中的表达]

[Expression of transforming growth factor-β(1) and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma].

作者信息

Lao Jun-Ping, Chen Ju-Feng

机构信息

Department of Stomatology, The First Hospital of Foshan, Sun Yat-san University, Guangdong Foshan 528000, China.

出版信息

Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Jan;46(1):20-3.

PMID:21418940

Abstract

OBJECTIVE

To investigate the expression and significance of transforming growth factor-β(1) (TGF-β(1)) and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma.

METHODS

The expression of TGF-β(1) and Ki-67 nuclear antigen in 20 cases of salivary gland pleomorphic adenoma and 45 cases of mucoepidermoid carcinoma were detected by the streptavidin-peroxidase immunohistochemical method.

RESULTS

Expression of TGF-β(1) (39/45) and Ki-67 nuclear antigen (43/45) in mucoepidermoid carcinoma was significantly higher than in pleomorphic adenoma (P < 0.05). TGF-β(1) expression was significantly higher in moderately/poorly differentiated mucoepidermoid carcinoma (16/16) than that in well differentiated mucoepidermoid carcinoma (23/29) and pleomorphic adenoma (12/20) (P < 0.05), but not different between well differentiated mucoepidermoid carcinoma (6/23) and pleomorphic adenoma (8/12) (P > 0.05). The expression of Ki-67 was increased with the increment of TGF-β(1) expression in mucoepidermoid carcinoma (P < 0.05).

CONCLUSIONS

The high expression of TGF-β(1) may play an important role in cell differentiation and malignant proliferation of mucoepidermoid carcinoma.

摘要

目的

探讨转化生长因子-β(1)（TGF-β(1)）及Ki-67核抗原在涎腺黏液表皮样癌中的表达及意义。

方法

采用链霉亲和素-过氧化物酶免疫组化法检测20例涎腺多形性腺瘤和45例黏液表皮样癌中TGF-β(1)及Ki-67核抗原的表达。

结果

黏液表皮样癌中TGF-β(1)（39/45）及Ki-67核抗原（43/45）的表达显著高于多形性腺瘤（P < 0.05）。中/低分化黏液表皮样癌（16/16）中TGF-β(1)的表达显著高于高分化黏液表皮样癌（23/29）及多形性腺瘤（12/20）（P < 0.05），但高分化黏液表皮样癌（6/23）与多形性腺瘤（8/12）之间差异无统计学意义（P > 0.05）。黏液表皮样癌中Ki-67的表达随TGF-β(1)表达的增加而升高（P < 0.05）。