Scarpignato C, Pezzetta A, Tarditi E
Horm Res. 1986;24(4):295-301. doi: 10.1159/000180570.
The effect of caerulein (100 ng/kg/h X 1 h) on basal as well as on thyrotropin-releasing hormone (TRH)-stimulated prolactin and thyroid-stimulating hormone (TSH) secretion was studied in healthy male volunteers. The peptide did not change the basal levels of prolactin and TSH. However, during the infusion of caerulein, prolactin response to TRH was significantly increased whereas the TSH response was decreased. These data, showing an action of caerulein (a frog peptide which mimics the biological actions of cholecystokinin) on prolactin and TSH release, suggest that cholecystokinin may be involved in the physiological control of human pituitary secretion.
在健康男性志愿者中研究了蛙皮素（100纳克/千克/小时×1小时）对基础状态以及促甲状腺激素释放激素（TRH）刺激的催乳素和促甲状腺激素（TSH）分泌的影响。该肽未改变催乳素和TSH的基础水平。然而，在输注蛙皮素期间，催乳素对TRH的反应显著增加，而TSH反应则降低。这些数据表明蛙皮素（一种模拟胆囊收缩素生物学作用的蛙肽）对催乳素和TSH释放有作用，提示胆囊收缩素可能参与人类垂体分泌的生理控制。
