Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Centre Rotterdam, Postbox 2040, 3000 CA Rotterdam, the
Eur Cell Mater. 2019 Apr 10;37:277-291. doi: 10.22203/eCM.v037a17.
Endochondral ossification (EO) is the process by which the long bones of the body form and has proven to be a promising method in tissue engineering for achieving cell-mediated bone formation. The present review centred on state-of-the-art research pertaining to mesenchymal stem cells (MSCs)-mediated endochondral bone formation, focusing on the role of donor cells, extracellular matrix and host immune cells during tissue-engineered bone formation. Possible research avenues to improve graft outcome and bone output were highlighted, as well as emerging research that, when applied to tissue-engineered bone grafts, offers new promise for improving the likelihood of such grafts transition from bench to bedside.
软骨内骨化（EO）是身体长骨形成的过程，已被证明是组织工程中实现细胞介导骨形成的有前途的方法。本综述集中于与间充质干细胞（MSCs）介导的软骨内骨形成相关的最新研究，重点介绍了在组织工程骨形成过程中供体细胞、细胞外基质和宿主免疫细胞的作用。强调了可能的研究途径，以改善移植物的效果和骨输出，并介绍了新兴的研究，当应用于组织工程骨移植物时，为提高这些移植物从实验室到临床的可能性提供了新的希望。
