Hormone therapy is not associated with the risk of sudden sensorineural hearing loss in postmenopausal women: a 10-year nationwide population-based study.

OBJECTIVE

The association between hormone therapy (HT) and the risk for sudden sensorineural hearing loss (SSNHL) in postmenopausal women has been described only in case reports. No large study has further evaluated the association between HT and the risk of SSNHL in postmenopausal women. The objective of our study was to investigate whether postmenopausal women with HT exhibit a risk of SSNHL.

METHODS

This matched cohort study enrolled 13,112 postmenopausal women 45 to 79 years of age who used HT between 2000 and 2010; they were selected from the National Health Insurance Research Database of Taiwan, and 39,336 participants without HT use were enrolled as controls matched by age and index year at a 1:3 ratio.

RESULTS

We used a Cox proportional hazards regression model to identify the risk of SSNHL during 10 years of follow-up, and the results indicated no significant increase in the proportion of postmenopausal women with HT use (P = 0.814) who developed SSNHL compared with those without HT use (1.14%, 150/13, 112 vs 1.12%, 439/39, 336). After adjustment for age and other variables, the adjusted hazard ratio was 0.78 (95% CI, 0.308-1.025, P = 0.762) and showed no association between HT use and SSNHL development in postmenopausal women.

CONCLUSIONS

Our results showed that HT was not associated with the risk of SSNHL in postmenopausal women over a 10-year follow-up study.