金黄色葡萄球菌中 pristinamycin 协同作用的研究。

Studies on pristinamycin synergism in Staphylococcus aureus.

作者信息

Lacroix P, Aumercier M, Capmau M L, Le Goffic F

出版信息

J Antibiot (Tokyo). 1986 Sep;39(9):1314-21. doi: 10.7164/antibiotics.39.1314.

DOI:10.7164/antibiotics.39.1314

Abstract

Binding experiments were performed with both components of the pristinamycin complex (pristinamycin IA (PIA) and pristinamycin IIA (PIIA] using ribosomes from sensitive and resistant Staphylococcus aureus. Fluorescence polarization was used to measure PIA binding. The results obtained show a direct correlation between inhibition, synergy and the enhancement of the affinity of PIA for its receptor in the presence of PIIA. The uptake of PIA by intact cells seems to be directly correlated with affinity between PIA and ribosomes, a phenomenon which is probably shared with the macrolide antibiotics.

摘要

使用敏感和耐药金黄色葡萄球菌的核糖体，对 pristinamycin 复合物的两种成分（pristinamycin IA（PIA）和 pristinamycin IIA（PIIA））进行结合实验。采用荧光偏振法测定 PIA 的结合情况。所得结果表明，在存在 PIIA 的情况下，抑制、协同作用与 PIA 对其受体亲和力的增强之间存在直接关联。完整细胞对 PIA 的摄取似乎与 PIA 和核糖体之间的亲和力直接相关，这一现象可能与大环内酯类抗生素相同。