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普那霉素对耐甲氧西林金黄色葡萄球菌的体外活性

In vitro activity of pristinamycin against methicillin-resistant Staphylococcus aureus.

作者信息

Mutton K J, Andrew J H

出版信息

Chemotherapy. 1983;29(3):218-24. doi: 10.1159/000238200.

DOI:10.1159/000238200
PMID:6409520
Abstract

An agar dilution technique was used to determine the MIC of pristinamycin for 124 clinical isolates of methicillin-resistant Staphylococcus aureus. All were inhibited by less than or equal to 0.5 mg/1, quite similar to the sensitivity of a number of methicillin-sensitive strains. MICs obtained using a microdilution method were also comparable. Antagonism was seen with the combination of pristinamycin and erythromycin.

摘要

采用琼脂稀释法测定了124株耐甲氧西林金黄色葡萄球菌临床分离株对普那霉素的最低抑菌浓度(MIC)。所有菌株均被0.5mg/1及以下浓度所抑制,这与许多甲氧西林敏感菌株的敏感性相当。使用微量稀释法获得的最低抑菌浓度也具有可比性。观察到普那霉素与红霉素联合使用存在拮抗作用。

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