质粒介导的普那霉素耐药性。PAC IIA：一种修饰普那霉素IIA的新酶。

Plasmid-mediated pristinamycin resistance. PAC IIA: a new enzyme which modifies pristinamycin IIA.

作者信息

Goffic F L, Capmau M L, Bonnet D, Cerceau C, Soussy C, Dublanchet A, Duval J

出版信息

J Antibiot (Tokyo). 1977 Aug;30(8):665-9. doi: 10.7164/antibiotics.30.665.

DOI:10.7164/antibiotics.30.665

Abstract

A wild strain of Staphylococcus aureus which inactivates a wide variety of antibiotics has been found to inactivate pristinamycin IIA, an antistaphylococcal antibiotic. This phenomenon has been demonstrated to be plasmid mediated. The plasmid directs the biosynthesis of an acetyltransferase which is able to O-acetylate the drug. We propose to call the new enzyme PAC (IIA): Pristinamycin acetyltransferase.

摘要

已发现一种能使多种抗生素失活的金黄色葡萄球菌野生菌株可使抗葡萄球菌抗生素普那霉素IIA失活。这种现象已被证明是由质粒介导的。该质粒指导一种乙酰转移酶的生物合成，这种乙酰转移酶能够将药物进行O-乙酰化。我们提议将这种新酶称为PAC（IIA）：普那霉素乙酰转移酶。