对仅有支持细胞的睾丸组织学男性进行睾丸精子提取——1680例病例。
Testicular sperm extraction in men with sertoli cell-only testicular histology - 1680 cases.
作者信息
Taitson Paulo Franco, Mourthé Antônio, Radaelli Moacir Rafael Martins
机构信息
Human Reproduction Discipline, DCB/ICBS, Pontifícia Universidade Católica de Minas Gerais. Belo Horizonte, MG, Brazil.
ICBS, Pontifícia Universidade Católica de Minas Gerais. Belo Horizonte, MG, Brazil.
出版信息
JBRA Assist Reprod. 2019 Aug 22;23(3):246-249. doi: 10.5935/1518-0557.20190023.
OBJECTIVE
To study the outcomes of testicular sperm extraction (TESE) among men with pure Sertoli cell-only histology identified during diagnostic testicular biopsy.
METHODS
This retrospective cohort study involved 1680 cases of patients with nonobstructive azoospermia (NOA) diagnosed with pure Sertoli cell-only histology who underwent testicular biopsy with TESE in a reference center in Brazil by a single surgeon. Sperm retrieval rates (SSR) were the main outcome measure.
RESULTS
Overall, 14.83% of patients with Sertoli cell-only had sperm retrieved with TESE in quantity that allowed the performance of ICSI. No differences were observed in SSR based on testis volume (<15 mL vs. <15 mL) or serum FSH level.
CONCLUSIONS
Patients with Sertoli cell-only histology can be counseled that they have some likelihood of sperm retrieval with TESE. Based on the findings, patients to be submitted to testicular biopsy for histologic analysis may be concomitantly prepared for ICSI with TESE in case sperm is available.
目的
研究在诊断性睾丸活检中确诊为单纯支持细胞组织学的男性患者进行睾丸精子提取（TESE）的结果。
方法
这项回顾性队列研究纳入了1680例非梗阻性无精子症（NOA）患者，这些患者被诊断为单纯支持细胞组织学，并在巴西的一个参考中心由一名外科医生进行了睾丸活检及TESE。精子获取率（SSR）是主要的观察指标。
结果
总体而言，单纯支持细胞患者中有14.83%通过TESE获取到了数量足以进行卵胞浆内单精子注射（ICSI）的精子。基于睾丸体积（<15 mL与≥15 mL）或血清卵泡刺激素（FSH）水平，未观察到SSR有差异。
结论
对于单纯支持细胞组织学的患者，可以告知他们通过TESE有一定的精子获取可能性。基于这些发现，对于因组织学分析而需要进行睾丸活检的患者，若有精子可用，可同时为进行TESE联合ICSI做好准备。
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