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细菌糖原的生物合成。从glgA基因的核苷酸序列推导大肠杆菌ADP-葡萄糖：α-1,4-葡聚糖、4-葡糖基转移酶的一级结构。

Biosynthesis of bacterial glycogen. Primary structure of Escherichia coli ADP-glucose:alpha-1,4-glucan, 4-glucosyltransferase as deduced from the nucleotide sequence of the glgA gene.

作者信息

Kumar A, Larsen C E, Preiss J

出版信息

J Biol Chem. 1986 Dec 5;261(34):16256-9.

PMID:3097003
Abstract

The nucleotide sequence of the glgA gene, coding for glycogen synthase (EC 2.4.1.21) was elucidated. It consists of 1431 base pairs specifying a protein of 477 amino acids. The deduced amino acid sequence was consistent with the amino acid analysis obtained with the pure protein as well as with the molecular weight as determined from sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The deduced amino acid sequence was also consistent with the amino-terminal acid sequence and amino acid sequence analysis of various peptides obtained from CNBr degradation of purified glycogen synthase.

摘要

对编码糖原合酶（EC 2.4.1.21）的glgA基因的核苷酸序列进行了阐明。它由1431个碱基对组成，指定了一个由477个氨基酸组成的蛋白质。推导的氨基酸序列与用纯蛋白质进行的氨基酸分析以及从十二烷基硫酸钠-聚丙烯酰胺凝胶电泳确定的分子量一致。推导的氨基酸序列也与从纯化的糖原合酶的CNBr降解获得的各种肽的氨基末端氨基酸序列和氨基酸序列分析一致。

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