Institute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Int J Environ Res Public Health. 2019 Apr 9;16(7):1258. doi: 10.3390/ijerph16071258.
An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size ( = 0.4), and were diagnosed at a similar age ( = 0.2) compared to a subset of thyroid cancer cases treated at Mount Sinai without WTC exposure. These results do not support the surveillance bias hypothesis, under which smaller tumors are expected to be diagnosed at earlier ages. WTCHP thyroid cancer cases also reported a past history of radiation exposure and a family history of thyroid conditions at lower rates than expected, with higher than expected rates of previous cancer diagnoses, family histories of other cancers, and high Body Mass Indexes (BMIs). Further research is needed to better understand the underlying risk factors that may play a role in the development of thyroid cancer in this group.
有报道称，9/11 救援人员中甲状腺癌的发病率有所增加，其病因尚不清楚，但至少部分原因可能是该人群接受了更多的医疗监测。本研究旨在通过观察西奈山 9/11 健康计划（WTCHP）中甲状腺癌病例的人口统计学数据和问卷调查结果，来研究世贸中心（WTC）救援人员中的甲状腺癌。WTCHP 的甲状腺癌肿瘤大小相似（=0.4），诊断年龄也相似（=0.2），与西奈山未接触 WTC 的一组甲状腺癌病例相比。这些结果不支持监测偏差假说，根据该假说，预计较小的肿瘤会在更早的年龄被诊断出来。WTCHP 的甲状腺癌病例报告的既往辐射暴露史和甲状腺疾病家族史的发生率也低于预期，而既往癌症诊断、其他癌症家族史和高身体质量指数（BMI）的发生率则高于预期。需要进一步研究，以更好地了解可能在该人群中甲状腺癌发展中起作用的潜在风险因素。
