Mantione Daniele, Del Agua Isabel, Sanchez-Sanchez Ana, Mecerreyes David
Polymat University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018 Donostia-San Sebastian, Spain.
Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541 Gardanne, France.
Polymers (Basel). 2017 Aug 11;9(8):354. doi: 10.3390/polym9080354.
Poly(3,4-ethylenedioxythiophene)s are the conducting polymers (CP) with the biggest prospects in the field of bioelectronics due to their combination of characteristics (conductivity, stability, transparency and biocompatibility). The gold standard material is the commercially available poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS). However, in order to well connect the two fields of biology and electronics, PEDOT:PSS presents some limitations associated with its low (bio)functionality. In this review, we provide an insight into the synthesis and applications of innovative poly(ethylenedioxythiophene)-type materials for bioelectronics. First, we present a detailed analysis of the different synthetic routes to (bio)functional dioxythiophene monomer/polymer derivatives. Second, we focus on the preparation of PEDOT dispersions using different biopolymers and biomolecules as dopants and stabilizers. To finish, we review the applications of innovative PEDOT-type materials such as biocompatible conducting polymer layers, conducting hydrogels, biosensors, selective detachment of cells, scaffolds for tissue engineering, electrodes for electrophysiology, implantable electrodes, stimulation of neuronal cells or pan-bio electronics.
聚（3,4-乙撑二氧噻吩）类是生物电子学领域中最具前景的导电聚合物（CP），因为它们具备多种特性（导电性、稳定性、透明度和生物相容性）。金标准材料是市售的聚（3,4-乙撑二氧噻吩）：聚（苯乙烯磺酸盐）（PEDOT:PSS）。然而，为了很好地连接生物学和电子学这两个领域，PEDOT:PSS存在一些与其低（生物）功能性相关的局限性。在本综述中，我们深入探讨了用于生物电子学的新型聚（乙撑二氧噻吩）类材料的合成与应用。首先，我们详细分析了制备（生物）功能性二氧噻吩单体/聚合物衍生物的不同合成路线。其次，我们重点关注使用不同生物聚合物和生物分子作为掺杂剂和稳定剂来制备PEDOT分散体。最后，我们综述了新型PEDOT类材料的应用，如生物相容性导电聚合物层、导电水凝胶、生物传感器、细胞的选择性分离、组织工程支架、电生理学电极、可植入电极、神经元细胞刺激或泛生物电子学。
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