Kitzerow Janina, Teufel Karoline, Jensen Katrin, Wilker Christian, Freitag Christine M
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Center of Excellence Frankfurt, Goethe University Frankfurt am Main, Germany.
Institute of Medical Biometry and Informatics, University of Heidelberg, Germany.
Z Kinder Jugendpsychiatr Psychother. 2020;48(2):103-112. doi: 10.1024/1422-4917/a000661. Epub 2019 Apr 11.
Abstracts: Objective: In current international research, early intervention in children with autism-spectrum disorder (ASD) focuses on naturalistic developmental behavioral interventions (NDBI). The manualized Frankfurt Early Intervention Program for preschool-aged children with ASD (A-FFIP) implements NDBI principles within a low-intensity approach of 2 h intervention/week. The present case-control study established effect sizes of change in autistic symptoms, comorbid behavioral problems as well as IQ after one year. Methodology: An intervention group (N = 20; age: 3.4-7.9 years) and a treatment-as-usual control group (N = 20; age: 3.2-7.3 years) of children with ASD were matched for developmental and chronological age. The outcome measures used were the ADOS severity score, the Child Behavior Checklist, and cognitive development. Results: After one year, the A-FFIP group showed a trend towards greater improvement in autistic symptoms (η2 = .087 [95 %-CI: .000-.159]) and significantly greater improvements in cognitive development (η2 = .206 [CI: .012-.252]) and global psychopathology (η2 = .144 [CI: .001-.205]) compared to the control group. Conclusion: The efficacy of A-FFIP should be established in a larger, sufficiently powered, randomized controlled study.
目的：在当前国际研究中，对自闭症谱系障碍（ASD）儿童的早期干预主要集中在自然发展行为干预（NDBI）。针对学龄前ASD儿童的法兰克福早期干预手册化项目（A - FFIP）在每周2小时的低强度干预模式下实施NDBI原则。本病例对照研究确定了一年后自闭症症状、共病行为问题以及智商变化的效应量。方法：将一组自闭症儿童干预组（N = 20；年龄：3.4 - 7.9岁）和一组常规治疗对照组（N = 20；年龄：3.2 - 7.3岁）按照发育年龄和实际年龄进行匹配。所使用的结果测量指标为自闭症诊断观察量表严重程度得分、儿童行为检查表以及认知发展。结果：一年后，与对照组相比，A - FFIP组在自闭症症状改善方面呈现出更大改善的趋势（η² = .087 [95%置信区间：.000 -.159]），在认知发展（η² = .206 [置信区间：.012 -.252]）和总体精神病理学（η² = .144 [置信区间：.001 -.205]）方面有显著更大的改善。结论：A - FFIP的疗效应在一项更大规模、有足够效力的随机对照研究中得到验证。
