操纵子启动子在控制重组蛋白生产中的应用。
Exploitation of the operon promoter for controlled recombinant protein production.
机构信息
Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, U.K.
School of Biosciences, University of Kent, Ingram Building, Canterbury CT2 7NJ, U.K.
出版信息
Biochem Soc Trans. 2019 Apr 30;47(2):755-763. doi: 10.1042/BST20190059. Epub 2019 Apr 10.
PMID:30971435
Abstract
The operon promoter is widely used as a tool to control recombinant protein production in bacteria. Here, we give a brief review of how it functions, how it is regulated, and how, based on this knowledge, a suite of promoter derivatives has been developed to give a controlled expression that is suitable for diverse biotechnology applications.
摘要
操纵子启动子被广泛用作控制细菌中重组蛋白生产的工具。在这里，我们简要回顾了它的功能、如何调控，以及如何基于这些知识开发了一系列启动子衍生物，以实现适合各种生物技术应用的可控表达。
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