Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Indian J Dermatol Venereol Leprol. 2019 Jul-Aug;85(4):374-379. doi: 10.4103/ijdvl.IJDVL_49_18.
Leukotrichia has been considered a predictor of poor outcome in vitiligo. However, studies considering the different clinical aspects of leukotrichia in vitiligo patients are few.
Our aim was to conduct a detailed clinical study to provide insights into the relevance and associations of leukotrichia in non-segmental vitiligo.
In this cross-sectional study, vitiligo patients attending the dermatology outpatient clinic and phototherapy unit at Cairo University Hospital over a period of 6 months (April-September 2016) were included. Family history, clinical details, the Vitiligo Global Issues Consensus Conference classification, the Dermatology Life Quality Index, Vitiligo Area and Severity Index, Vitiligo Extent Score, Vitiligo Disease Activity Score and Vellus Score were determined and these measurements were correlated to leukotrichia.
Out of the 101 patients studied, leukotrichia was found in 47 (46.5%) patients, with vellus hair involved in 37 (78.7%), terminal hairs in 30 (63.8%) and both in 20 (42.5%) patients. Vellus hair involvement was significantly higher in generalized bilaterally symmetrical vitiligo than in acrofacial or unclassified vitiligo. The incidence of scalp leukotrichia also was higher in generalized symmetrical vitiligo than in acrofacial vitiligo. The Vellus Score showed significant associations with Vitiligo Area and Severity Index, Vitiligo Extent Score and the Dermatology Life Quality Index.
This was a short-term study with a small sample size. Prognostic and therapeutic correlations were not studied; prospective longitudinal studies are needed for further evaluation.
Leukotrichia was found in almost half of the studied sample and its frequency varied among the different types of vitiligo.
白发已被认为是白癜风预后不良的一个预测因素。然而，关于白癜风患者中不同临床类型的白发的研究较少。
我们旨在进行一项详细的临床研究，以深入了解非节段性白癜风中白发的相关性和关联。
在这项横断面研究中，纳入了在 2016 年 4 月至 9 月期间在开罗大学医院皮肤科门诊和光疗科就诊的白癜风患者。记录了家族史、临床细节、白癜风全球问题共识会议分类、皮肤病生活质量指数、白癜风面积和严重程度指数、白癜风扩展评分、白癜风疾病活动评分和毳毛评分，并将这些测量值与白发相关联。
在研究的 101 名患者中，发现 47 名（46.5%）患者有白发，其中 37 名（78.7%）有毳毛受累，30 名（63.8%）有终毛受累，20 名（42.5%）有毳毛和终毛同时受累。广泛性双侧对称型白癜风患者的毳毛受累明显高于肢端型或未分类型白癜风患者。头皮白发的发生率在广泛性对称型白癜风中也高于肢端型白癜风。毳毛评分与白癜风面积和严重程度指数、白癜风扩展评分和皮肤病生活质量指数显著相关。
这是一项短期研究，样本量较小。未研究预后和治疗相关性；需要进行前瞻性纵向研究以进一步评估。
在研究的样本中，发现几乎有一半的患者有白发，其频率在不同类型的白癜风中有所不同。
