mRNA 疫苗在传染病防治中的进展
Advances in mRNA Vaccines for Infectious Diseases.
机构信息
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
GSK, Rockville, MD, United States.
出版信息
Front Immunol. 2019 Mar 27;10:594. doi: 10.3389/fimmu.2019.00594. eCollection 2019.
During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.
在过去的二十年中，人们对基于 RNA 的技术在预防性和治疗性疫苗开发方面产生了广泛的兴趣。临床前和临床试验表明，mRNA 疫苗在动物模型和人类中提供了安全且持久的免疫应答。在这篇综述中，我们总结了当前 mRNA 疫苗的研究进展，这些疫苗有可能快速制造，并成为对抗传染病的有力工具，我们还强调了它们设计和应用的光明前景。
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