Liu Shaochuan, Qin Tingting, Jia Yanan, Li Kai
National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Front Oncol. 2019 Mar 26;9:189. doi: 10.3389/fonc.2019.00189. eCollection 2019.
To elucidate the relationship between VEGFA and PD-L1 expression in lung adenocarcinoma (LADC). PD-L1 and VEGFA expression were determined by immunohistochemistry with H-score on formalin-fixed paraffin-embedded resected LADC specimens of 129 cases. High PD-L1 expression in 53 (41.1%) patients, high VEGFA expression in 65 (50.4%), and co-expression in 18 (14.0%) were observed. Inverse correlation between expression of PD-L1 and VEGFA was found ( = 0.002, = -0.274). VEGFA and PD-L1 expression were not significantly associated with the clinicopathological features. High PD-L1 expression was significantly association with all patients' poor progression-free survival and overall survival in a univariate analysis, but there was no significantly association with high VEGFA expression and prognosis. Co-expression of PD-L1 and VEGFA exhibited a worst overall survival compared to negative groups ( = 0.005). These findings indicate that high PD-L1 expression could impact both poor overall survival and progression-free survival in patients with resected LADC. Co-expression of PD-L1 and VEGFA may be considered as an important prognostic factor for patients with resected lung adenocarcinoma.
为阐明肺腺癌（LADC）中血管内皮生长因子A（VEGFA）与程序性死亡受体配体1（PD-L1）表达之间的关系。采用免疫组织化学法并通过H评分，对129例福尔马林固定石蜡包埋的LADC切除标本进行PD-L1和VEGFA表达检测。观察到53例（41.1%）患者PD-L1高表达，65例（50.4%）患者VEGFA高表达，18例（14.0%）患者二者共表达。发现PD-L1与VEGFA表达呈负相关（P = 0.002，r = -0.274）。VEGFA和PD-L1表达与临床病理特征无显著相关性。单因素分析显示，PD-L1高表达与所有患者的无进展生存期和总生存期较差显著相关，但VEGFA高表达与预后无显著相关性。与阴性组相比，PD-L1和VEGFA共表达患者的总生存期最差（P = 0.005）。这些发现表明，PD-L1高表达可能影响LADC切除患者的总生存期和无进展生存期。PD-L1和VEGFA共表达可被视为LADC切除患者的一个重要预后因素。
