State Key Laboratory of Applied Organic Chemistry Lanzhou University and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou 730000, China.
Dalton Trans. 2019 Apr 23;48(17):5735-5740. doi: 10.1039/c9dt00202b.
At present, though calcium (Ca) reagents with high calcium contents are widely synthesized, their wide application is limited due to their low absorption rates and poor bioavailability. Here we use a carboxymethyl cellulose (CMC) derivative with high water solubility and biocompatibility as a ligand to bind Ca2+. The resulting CaCMC complex exhibits remarkable solubility and absorbability under both basic and acidic conditions as well as in stomach mimicking and the gastrointestinal tract. Importantly, this Ca reagent shows high in vivo calcium bioavailability. Data from osteoporosis mouse models show that the CaCMC complex is superior to calcium carbonate in the treatment of osteoporosis. Therefore, the resulting CaCMC complex is used as a new, highly effective and desirable Ca supplement for daily life and clinical applications.
目前，尽管高钙含量的钙试剂被广泛合成，但由于其吸收率低和生物利用度差，其应用受到限制。在这里，我们使用一种具有高水溶性和生物相容性的羧甲基纤维素（CMC）衍生物作为配体与 Ca2+结合。所得的 CaCMC 复合物在碱性和酸性条件下以及在模拟胃和胃肠道中均表现出显著的溶解性和吸收性。重要的是，这种钙试剂具有很高的体内钙生物利用度。骨质疏松症小鼠模型的数据表明，与碳酸钙相比，CaCMC 复合物在治疗骨质疏松症方面具有优势。因此，所得的 CaCMC 复合物被用作日常生活和临床应用中一种新的、高效和理想的钙补充剂。
