Duggirala Naga Kiran, Li Jinghan, Kumar N S Krishna, Gopinath Tata, Suryanarayanan Raj
Department of Pharmaceutics, University of Minnesota, MN-55455, USA.
Chem Commun (Camb). 2019 May 9;55(39):5551-5554. doi: 10.1039/c9cc02021g.
A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.
采用超分子合成子方法设计了含有氨基芳族氮部分和聚丙烯酸聚合物的药物无定形固体分散体（ASD）。通过差示扫描量热法、光谱法（红外光谱和15N核磁共振）以及X射线晶体学证实了药物与聚合物之间的相互作用。这种相互作用降低了分子流动性，赋予了优异的物理稳定性并提高了药物溶出度。
