Center of Neurodevelopmental Disorders (KIND), Division of Neuropsychiatry, Department of Women's and Children's Health, Center for Psychiatry Research, Karolinska Institutet & Region Stockholm, Stockholm, Sweden.
Child and Adolescent Psychiatry, Region Stockholm, Stockholm, Sweden.
J Autism Dev Disord. 2019 Jul;49(7):2838-2848. doi: 10.1007/s10803-019-04001-4.
Alterations in social cognition (SC) are hypothesized to underlie social communication and interaction challenges in autism spectrum disorder (ASD). The aetiological underpinnings driving this association remain unclear. We examined SC in 196 twins with ASD, other neurodevelopmental disorders or typical development using the naturalistic Movie for the Assessment of Social Cognition. Autism and its severity were assessed with the Autism Diagnostic Observation Schedule-2, and autistic traits with the Social Responsiveness Scale-2. Using within twin-pair regression models, controlling for age, sex, IQ, and unmeasured familial confounders such as genetic background and shared-environment, SC correlated with ASD diagnosis, autism severity, and autistic traits. Our findings highlight the importance of SC alterations in autism and suggest a non-shared environmental impact on the association.
社交认知 (SC) 的改变被认为是自闭症谱系障碍 (ASD) 中社交沟通和互动挑战的基础。但导致这种关联的病因基础仍不清楚。我们使用自然主义电影评估社交认知 (Movie for the Assessment of Social Cognition) ，对 196 名患有 ASD、其他神经发育障碍或典型发育的双胞胎进行了 SC 评估。自闭症及其严重程度使用自闭症诊断观察量表-2（Autism Diagnostic Observation Schedule-2）进行评估，自闭症特征使用社交反应量表-2（Social Responsiveness Scale-2）进行评估。使用双胞胎内回归模型，控制年龄、性别、智商以及未测量的家族混杂因素（如遗传背景和共享环境），SC 与 ASD 诊断、自闭症严重程度和自闭症特征相关。我们的研究结果强调了 SC 改变在自闭症中的重要性，并表明对这种关联有非共享环境的影响。
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