Hoefnagel C A, Delprat C C, Marcuse H R, de Vijlder J J
J Nucl Med. 1986 Dec;27(12):1854-7.
To evaluate the reliability of total-body scintigraphy using [201Tl]chloride in postoperative follow-up of thyroid carcinoma, this procedure was performed in 326 patients after total thyroidectomy for thyroid carcinoma. The results were compared with those of 131I scintigraphy and thyroglobulin assays. 201Tl total-body scintigraphy was found to have the greatest sensitivity (94%), whereas 131I scintigraphy had the highest specificity (99%). It is shown that 201Tl total-body scintigraphy is a useful procedure in follow-up of thyroid cancer, however, the combination of parameters provides the greatest reliability. In medullary thyroid carcinoma, which is usually 131I negative, 201Tl total-body scintigraphy can be of great value for the localization of metastases which are indicated by elevated serum levels of calcitonin and carcinoembryonic antigen.
为评估氯化[201Tl]全身闪烁扫描在甲状腺癌术后随访中的可靠性，对326例行甲状腺癌全甲状腺切除术后的患者进行了该检查。将结果与131I闪烁扫描及甲状腺球蛋白测定结果进行比较。发现201Tl全身闪烁扫描的敏感性最高（94%），而131I闪烁扫描的特异性最高（99%）。结果表明，201Tl全身闪烁扫描在甲状腺癌随访中是一种有用的检查方法，然而，参数组合可提供最高的可靠性。在通常131I阴性的甲状腺髓样癌中，201Tl全身闪烁扫描对于由降钙素和癌胚抗原血清水平升高所提示的转移灶定位可能具有重要价值。
