Health Services Vocational School, Iğdır University, Iğdır, Turkey.
Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey.
J Biochem Mol Toxicol. 2019 Aug;33(8):e22340. doi: 10.1002/jbt.22340. Epub 2019 Apr 11.
Multiple studies have been recorded on the synthesis and design of multi-aim anti-Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer's disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α-glycosidase, α-amylase, and butyrylcholinesterase (BChE). IC values of tannic acid obtained 11.9 nM against α-glycosidase and 3.3 nM against α-amylase, respectively. In contrast, K values were found of 50.96 ± 2.18 µM against AChE and 53.17 ± 4.47 µM against BChE. α-Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.
已有多项研究记录了多靶点抗阿尔茨海默病分子的合成和设计。使用双丁酰基胆碱酯酶/乙酰胆碱酯酶抑制剂分子在阿尔茨海默病的治疗中引起了更多的关注。在这项研究中，鞣酸化合物对乙酰胆碱酯酶（AChE）、α-糖苷酶、α-淀粉酶和丁酰基胆碱酯酶（BChE）表现出优异的抑制作用。鞣酸对α-糖苷酶的 IC 值分别为 11.9 nM，对 α-淀粉酶的 IC 值分别为 3.3 nM。相比之下，鞣酸对 AChE 的 K 值为 50.96 ± 2.18 µM，对 BChE 的 K 值为 53.17 ± 4.47 µM。α-糖苷酶抑制剂化合物可用作新型抗糖尿病药物。通过竞争性降低糖苷酶活性，这些抑制剂分子有助于阻止糖分子的快速分解，从而控制血糖水平。
