Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Department of Biochemistry and Molecular Biology, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.
Molecules. 2022 Mar 6;27(5):1713. doi: 10.3390/molecules27051713.
Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people's lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity.
肥胖症和糖尿病是当今最具挑战性的健康问题,它们的患病率以及合并症在全球范围内都呈上升趋势。随着时间的推移,这两种疾病都成为了重大问题,对人们的生活产生了重大影响。糖尿病是一种代谢和内分泌疾病,其特征是由于胰岛素抵抗而导致的高血糖和葡萄糖不耐受。肥胖症是一种普遍存在的、复杂的、不断发展的整体健康问题,长期以来一直与人们的各种重大健康问题有关。由于草药产品种类繁多且副作用低,因此它们是药物开发的重要热点。合成化合物结构上没有多样性,缺乏药物相似性特征。因此,继续探索草药产品作为新型药物的潜在来源非常重要。我们通过搜索 Scopus、Science Direct、Elsevier、PubMed 和 Web of Science 数据库进行了本次文献综述。从 1990 年到 2021 年 10 月,我们展示了英语的研究报告、综述文章和原始研究文章。它提供了深入的数据和对可能用于治疗肥胖症或潜在抗糖尿病的植物衍生化合物的检查。深入了解植物化合物的作用机制,作为额外的研究,可以为代谢疾病的治疗方法的发展提供信息。在临床试验中,这些食物种类或治疗性植物中的许多以及它们的生物活性化合物已被证明对肥胖症的治疗有效。
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