College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China.
College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China; Engineering Research Center of Food Environment and Public Health, Beijing, 100081, China.
Ecotoxicol Environ Saf. 2019 Aug 15;177:86-92. doi: 10.1016/j.ecoenv.2019.04.007. Epub 2019 Apr 8.
Polychlorinated naphthalenes (PCNs) in the environment in China have been studied extensively. However, there have been no reports on PCNs in human serum samples from China. In this context, we collected 480 serum samples from an industrial city in Eastern China. The concentration range for the sum of the mono-to octa-CNs was 14300-50700 pg/g lipid. The most predominant congener was CN-5/7, which accounted for 21.6%-51.1% of the total PCN concentration. Further analysis indicated that residues of PCN industrial technical products in the local environment appear to be the main source of CN-5/7 in the serum samples. On the other hand, the sum of the tetra-to octa-CNs concentration was obviously higher in males (1390 ± 929 pg/g lipid) than in females (267 ± 25 pg/g lipid). Moreover, the concentrations of combustion-related PCNs in the male 20-24, 25-29 and 30-34 years groups were obviously higher than those in the female samples. Therefore, industrial thermal processes are important sources of PCNs in male serum in addition to PCN products. The toxic equivalent (TEQ) concentrations of PCNs in the pooled serum samples ranged from 0.12 to 0.40 pg/g lipid. CN-10 and CN-66/67 were the dominant TEQ congeners in male serum, and CN-10, CN-1, and CN-2 were the main TEQ congeners in female serum.
在中国，环境中的多氯萘（PCNs）已得到广泛研究。然而，目前尚未有关于中国人体血清样本中 PCNs 的报道。在此背景下，我们从中国东部一个工业城市采集了 480 份血清样本。单至八氯萘总和的浓度范围为 14300-50700 pg/g 脂质。最主要的同系物是 CN-5/7，占总 PCN 浓度的 21.6%-51.1%。进一步分析表明，当地环境中 PCN 工业技术产品的残留似乎是血清样本中 CN-5/7 的主要来源。另一方面，四氯至八氯萘的总和浓度在男性（1390±929 pg/g 脂质）中明显高于女性（267±25 pg/g 脂质）。此外，20-24、25-29 和 30-34 岁男性组中与燃烧有关的 PCN 浓度明显高于女性样本。因此，除了 PCN 产品之外，工业热工艺也是男性血清中 PCNs 的重要来源。混合血清样本中 PCNs 的毒性等效浓度（TEQ）范围为 0.12-0.40 pg/g 脂质。CN-10 和 CN-66/67 是男性血清中主要的 TEQ 同系物，而 CN-10、CN-1 和 CN-2 是女性血清中主要的 TEQ 同系物。
