School of Environmental Science & Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyojadong, Namgu, Pohang, Kyungbuk 790-784, Republic of Korea.
Environ Pollut. 2010 May;158(5):1420-7. doi: 10.1016/j.envpol.2009.12.039. Epub 2010 Jan 25.
Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) in human have been studied extensively; however, polychlorinated naphthalenes (PCNs) have been studied less widely. The mean concentrations of PCNs, PCDDs, PCDFs, and PCBs in 61 healthy human volunteers were 2170 pg/g lipid, 452 pg/g lipid, 116 pg/g lipid, and 120 ng/g lipid respectively, and the mean toxic equivalents (TEQs) contributed by PCNs, PCDDs, PCDFs, and PCBs were 5.88, 5.22, 5.48, and 5.33 pg/g lipid, respectively. PCNs contributed to 26.8% of the total TEQs. 1,2,3,7,8-PeCDD, 2,3,4,7,8-PeCDF, PCB126, and hepta-CN-73 accounted for >62% of the total TEQs in the human serum samples. The overall serum PCN homologue profiles of all subjects were dominated by tetra- and penta-CN homologues, and the most predominant individual congener was hepta-CN-73, which contributed 17.5% of the total serum PCN concentration. Enrichment of hepta-CN-73 in the human serum samples might be due to contributors from combustion sources.
多氯二苯并对二恶英（PCDDs）、多氯二苯并呋喃（PCDFs）和多氯联苯（PCBs）在人体内的研究已经很广泛了；然而，多氯萘（PCNs）的研究则相对较少。在 61 位健康志愿者的人体样本中，PCNs、PCDDs、PCDFs 和 PCBs 的平均浓度分别为 2170 pg/g 脂质、452 pg/g 脂质、116 pg/g 脂质和 120 ng/g 脂质，PCNs、PCDDs、PCDFs 和 PCBs 产生的毒性等效浓度（TEQs）分别为 5.88、5.22、5.48 和 5.33 pg/g 脂质。PCNs 对总 TEQs 的贡献率为 26.8%。1,2,3,7,8-五氯二苯并二恶英（1,2,3,7,8-PeCDD）、2,3,4,7,8-五氯二苯并呋喃（2,3,4,7,8-PeCDF）、PCB126 和七氯-73 占人体血清样本中总 TEQs 的>62%。所有受试者的血清 PCN 同系物图谱总体上以四氯和五氯同系物为主，最主要的单个同系物是七氯-73，占总血清 PCN 浓度的 17.5%。七氯-73 在人血清样本中的富集可能是由于燃烧源的贡献。
