National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 560029, Bengaluru, Karnataka, India.
National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, 560029, Bengaluru, Karnataka, India.
Asian J Psychiatr. 2019 Apr;42:74-78. doi: 10.1016/j.ajp.2019.03.012. Epub 2019 Mar 26.
Emerging evidence suggests a possible role for immune system dysregulation in the pathogenesis of postpartum psychosis (PP) but the evidence is limited. The current study sought to determine the serum cytokines/ chemokine changes associated with first-onset PP.
Women with first onset PP were recruited as cases and the cytokines/ chemokine changes were compared against healthy postpartum (HP) and healthy non-postpartum (HNP) women.There were 20 subjects in each of the three groups. Levels of serum cytokines and Monocyte Chemoattractant Protein-1 (MCP-1) were estimated with a cytometric beadarray assay.
HP group showed significantly elevated levels of interleukin (IL)-6 as compared to HNP group. Whereas, the first onset PP group showed significantly elevated levels of both IL-6 and IL-8 as compared to HNP group.
Postpartum period appears to be a state of altered immune functioning considering the elevated level of IL-6 in both HP and PP group. Additionally, IL-8 appears to play a role in the manifestation of PP. Our study highlights the immune alterations associated with first-onset PP.
新出现的证据表明免疫系统失调可能在产后精神病（PP）的发病机制中起作用，但证据有限。本研究旨在确定与首发 PP 相关的血清细胞因子/趋化因子变化。
将首发 PP 女性招募为病例，并将细胞因子/趋化因子变化与健康产后（HP）和健康非产后（HNP）女性进行比较。每组有 20 名受试者。使用流式细胞术 beadarray 检测法估计血清细胞因子和单核细胞趋化蛋白-1（MCP-1）的水平。
HP 组与 HNP 组相比，白细胞介素（IL）-6 水平显著升高。而首发 PP 组与 HNP 组相比，IL-6 和 IL-8 水平均显著升高。
考虑到 HP 和 PP 组中 IL-6 水平升高，产后期间似乎是一种免疫功能改变的状态。此外，IL-8 似乎在 PP 的表现中起作用。我们的研究强调了与首发 PP 相关的免疫改变。
