Dye Courtney, Lenz Kathryn M, Leuner Benedetta
Neuroscience Graduate Program, The Ohio State University, Columbus, OH, United States.
Department of Psychology, The Ohio State University, Columbus, OH, United States.
Front Glob Womens Health. 2022 Feb 10;2:758748. doi: 10.3389/fgwh.2021.758748. eCollection 2021.
The postpartum period is a time associated with high rates of depression and anxiety as well as greater risk for psychosis in some women. A growing number of studies point to aberrations in immune system function as contributing to postpartum mental illness. Here we review evidence from both clinical and animal models suggesting an immune component to postpartum depression, postpartum anxiety, and postpartum psychosis. Thus far, clinical data primarily highlights changes in peripheral cytokine signaling in disease etiology, while animal models have begun to provide insight into the immune environment of the maternal brain and how central inflammation may also be contributing to postpartum mental illnesses. Further research investigating peripheral and central immune function, along with neural and endocrine interactions, will be important in successfully developing novel prevention and treatment strategies for these serious disorders that impact a large portion of new mothers.
产后时期是一个与抑郁症和焦虑症高发相关的时期，对一些女性来说，患精神病的风险也更高。越来越多的研究指出，免疫系统功能异常是导致产后精神疾病的原因之一。在这里，我们回顾了来自临床和动物模型的证据，这些证据表明产后抑郁症、产后焦虑症和产后精神病存在免疫因素。到目前为止，临床数据主要强调了外周细胞因子信号在疾病病因中的变化，而动物模型已经开始深入了解母体大脑的免疫环境，以及中枢炎症如何也可能导致产后精神疾病。进一步研究外周和中枢免疫功能，以及神经和内分泌相互作用，对于成功开发针对这些严重疾病的新型预防和治疗策略至关重要，这些疾病影响了很大一部分新妈妈。
