验证癫痫患者神经障碍抑郁量表（NDDIE）作为中国人癫痫患者快速自杀筛查工具的有效性。
Validation of the Neurological Disorders Depression Inventory for Epilepsy (NDDIE) as a rapid suicidality screening tool in Chinese people with epilepsy.
机构信息
Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Lane 37#, Chengdu, Sichuan 610041, China; Department of Neurology, 363 Hospital, Daosangshu Road 108#, Chengdu, Sichuan 610041, China.
Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Lane 37#, Chengdu, Sichuan 610041, China.
出版信息
Epilepsy Behav. 2019 May;94:216-221. doi: 10.1016/j.yebeh.2019.03.024. Epub 2019 Apr 8.
OBJECTIVE
The objective of this study was to validate the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (NDDIE) as a suicidality screening tool in Chinese people with epilepsy (PWE).
METHODS
A consecutive cohort of PWE was recruited from West China Hospital and 363 Hospital. Each patient received a psychiatric evaluation with the Mini International Neuropsychiatric Interview (MINI) and the Chinese version of the NDDIE (C-NDDIE). Demographic and clinical characteristics were collected. Receiver operating characteristic (ROC) curve analysis was conducted. The best possible cutoff was identified with the highest Youden index. Specificity, sensitivity, positive, and negative predictive values were calculated.
RESULTS
Among a total of 355 participants, 41 (11.5%) had a moderate to high suicide risk according to the Suicidality Module (SM) of the MINI. Receiver operating characteristic (ROC) curve analysis showed that item 4 ("I'd be better off dead") of the NDDIE had an area under the curve (AUC) of 0.930 (95% confidence interval [CI] = 0.884-0.977), a sensitivity of 80.5%, a specificity of 94.9%, a positive predictive value (PPV) of 68.0%, a negative predictive value (NPV) of 97.7%, and the largest Youden index of 0.754 for a cutoff score of >2.
CONCLUSION
Item 4 of the NDDIE is a valuable tool for screening suicidality in Chinese PWE.
目的
本研究旨在验证中文版神经障碍抑郁量表（NDDIE）在中国癫痫患者（PWE）中作为自杀风险筛查工具的有效性。
方法
从华西医院和 363 医院连续招募了 PWE 患者。每位患者均接受了精神病学评估，包括迷你国际神经精神访谈（MINI）和中文版 NDDIE（C-NDDIE）。收集人口统计学和临床特征。进行了接收器工作特征（ROC）曲线分析。使用最高 Youden 指数确定最佳可能的截断值。计算了特异性、敏感性、阳性和阴性预测值。
结果
在总共 355 名参与者中，根据 MINI 的自杀模块（SM），有 41 人（11.5%）有中度至高度自杀风险。ROC 曲线分析显示，NDDIE 的第 4 项（“我死了会更好”）的曲线下面积（AUC）为 0.930（95%置信区间[CI] = 0.884-0.977），敏感性为 80.5%，特异性为 94.9%，阳性预测值（PPV）为 68.0%，阴性预测值（NPV）为 97.7%，截断值>2 时最大 Youden 指数为 0.754。
结论
NDDIE 的第 4 项是筛查中国 PWE 自杀风险的有用工具。
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