广泛性焦虑障碍-7（GAD-7）在中国癫痫患者中的效度验证。
Validation of the Generalized Anxiety Disorder-7 (GAD-7) among Chinese people with epilepsy.
作者信息
Tong Xin, An Dongmei, McGonigal Aileen, Park Sung-Pa, Zhou Dong
机构信息
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
出版信息
Epilepsy Res. 2016 Feb;120:31-6. doi: 10.1016/j.eplepsyres.2015.11.019. Epub 2015 Nov 28.
OBJECTIVE
To validate the Chinese version of the Generalized Anxiety Disorder-7 (GAD-7) in Chinese people with epilepsy (PWE).
METHODS
A consecutive cohort of PWE from the West China Hospital was recruited. Each patient received a psychiatric evaluation comprising the Mini International Neuropsychiatric Interview (MINI) and the GAD-7. Demographic and clinical characteristics were collected. Cronbach's α coefficient was calculated and receiver operating curve (ROC) analysis was conducted.
RESULTS
A total of 213 PWE completed the psychiatric evaluation. The GAD-7 was easily understood and quickly completed by all participants. Fifty patients (23.5%) had GAD according to the MINI criteria. Cronbach's α coefficient for the GAD-7 was 0.888. ROC analysis showed an area under the curve of 0.974 (95% CI=0.956-0.993). At a cut-off score of >6, the GAD-7 achieved the largest Youden index of 0.854 with a sensitivity of 94%, a specificity of 91.4%, a positive predictive value of 77% and a negative predictive value of 98%.
SIGNIFICANCE
The Chinese version of the GAD-7 is a valuable tool for screening for GAD in Chinese PWE.
目的
验证广泛性焦虑障碍-7（GAD-7）中文版在中国癫痫患者（PWE）中的有效性。
方法
招募来自华西医院的连续队列PWE。每位患者接受包括迷你国际神经精神访谈（MINI）和GAD-7在内的精神科评估。收集人口统计学和临床特征。计算Cronbach's α系数并进行受试者工作特征曲线（ROC）分析。
结果
共有213名PWE完成了精神科评估。所有参与者都能轻松理解并快速完成GAD-7。根据MINI标准，50名患者（23.5%）患有广泛性焦虑障碍。GAD-7的Cronbach's α系数为0.888。ROC分析显示曲线下面积为0.974（95%CI = 0.956 - 0.993）。在临界值>6时，GAD-7的约登指数最大，为0.854，敏感性为94%，特异性为91.4%，阳性预测值为77%，阴性预测值为98%。
意义
GAD-7中文版是筛查中国PWE广泛性焦虑障碍的有价值工具。
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