Desautels M, Dulos R A
Metabolism. 1986 Dec;35(12):1106-9. doi: 10.1016/0026-0495(86)90023-5.
The rate of oxygen consumption measured at 32.5 degrees C of lightly anesthetized 129/ReJ dy/dy mice was greater than that of dy/+ or +/+ control mice. However, the norepinephrine-stimulated rates of oxygen consumption of dystrophic and normal mice were similar. Brown adipose tissue cellularity (DNA content) of dystrophic mice was unchanged, and the tissue protein and succinate dehydrogenase contents were slightly reduced. The mitochondrial concentration of the uncoupling protein, thermogenin, and purine nucleotide binding to mitochondria isolated from brown fat of normal or dystrophic mice, were similar. These results indicate that the nonshivering thermogenic capacity of dystrophic mice is not significantly altered.
在32.5摄氏度下测量的轻度麻醉的129/ReJ dy/dy小鼠的耗氧率高于dy/+或+/+对照小鼠。然而，去甲肾上腺素刺激的营养不良小鼠和正常小鼠的耗氧率相似。营养不良小鼠的棕色脂肪组织细胞数量（DNA含量）没有变化，组织蛋白和琥珀酸脱氢酶含量略有降低。从正常或营养不良小鼠的棕色脂肪中分离出的线粒体的解偶联蛋白、产热素和嘌呤核苷酸与线粒体的结合浓度相似。这些结果表明，营养不良小鼠的非颤抖产热能力没有明显改变。
