• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

分子特刊简介:标题为“硫酸乙酰肝素和肝素研究中的一些突出问题”。

Introduction to the Molecules Special Edition Entitled '': Some Outstanding Questions in Heparan Sulfate and Heparin Research.

机构信息

Department of Biochemistry, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.

University of Manchester and Iduron Ltd, Biohub, Alderley Park, Alderley Edge, Cheshire SK10 4TG, UK.

出版信息

Molecules. 2019 Apr 10;24(7):1399. doi: 10.3390/molecules24071399.

DOI:10.3390/molecules24071399
PMID:30974725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6479682/
Abstract

The scope of this article is to provide a brief general introduction to heparan sulfate (HS) and heparin, and attempt to identify some of the central challenges regarding research into the chemistry and biology of glycosaminoglycans (GAGs), some of which are the subject of contributions to the special issue of (published in volume , 2018) entitled '' [...].

摘要

本文的范围是提供一个简要的肝素硫酸(HS)和肝素的一般介绍,并试图确定一些关于糖胺聚糖(GAGs)化学和生物学研究的核心挑战,其中一些是对题为“[......]”的专刊的贡献的主题(发表于 2018 年第 卷)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d1/6479682/f2b9372dbbe0/molecules-24-01399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d1/6479682/2bc52675b3ab/molecules-24-01399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d1/6479682/f2b9372dbbe0/molecules-24-01399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d1/6479682/2bc52675b3ab/molecules-24-01399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d1/6479682/f2b9372dbbe0/molecules-24-01399-g002.jpg

相似文献

1
Introduction to the Molecules Special Edition Entitled '': Some Outstanding Questions in Heparan Sulfate and Heparin Research.分子特刊简介:标题为“硫酸乙酰肝素和肝素研究中的一些突出问题”。
Molecules. 2019 Apr 10;24(7):1399. doi: 10.3390/molecules24071399.
2
Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate.细胞表面硫酸酯酶Sulf1亲水结构域上结合位点的协同作用,使得该酶与其底物硫酸乙酰肝素能够发生动态相互作用。
Biochim Biophys Acta. 2013 Nov;1830(11):5287-98. doi: 10.1016/j.bbagen.2013.07.014. Epub 2013 Jul 25.
3
Source-induced fragmentation of heparin, heparan, and galactosaminoglycans and application.肝素、硫酸乙酰肝素和半乳糖胺聚糖的源致断裂及其应用。
Anal Chem. 2009 Mar 15;81(6):2332-43. doi: 10.1021/ac802626e.
4
Recent advances in biotechnology for heparin and heparan sulfate analysis.肝素和硫酸乙酰肝素分析的生物技术最新进展。
Talanta. 2020 Nov 1;219:121270. doi: 10.1016/j.talanta.2020.121270. Epub 2020 Jun 14.
5
Strategies in Synthesis of Heparin/Heparan Sulfate Oligosaccharides: 2000-Present.肝素/硫酸乙酰肝素寡糖的合成策略:2000 年至今。
Adv Carbohydr Chem Biochem. 2021;80:121-164. doi: 10.1016/bs.accb.2021.11.003.
6
MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides.甘露聚糖结合凝集素丝氨酸蛋白酶 2 是一种肝素结合蛋白酶;阻断寡糖的鉴定。
Front Immunol. 2020 Apr 28;11:732. doi: 10.3389/fimmu.2020.00732. eCollection 2020.
7
Heparan sulfate and heparin as a potentiator or a suppressor of growth of normal and transformed vascular endothelial cells.硫酸乙酰肝素和肝素作为正常及转化血管内皮细胞生长的增强剂或抑制剂。
Exp Cell Res. 1987 Sep;172(1):92-100. doi: 10.1016/0014-4827(87)90096-6.
8
Advances in the separation, sensitive detection, and characterization of heparin and heparan sulfate.肝素和硫酸乙酰肝素在分离、灵敏检测及特性鉴定方面的进展。
Anal Bioanal Chem. 2009 Jan;393(1):155-69. doi: 10.1007/s00216-008-2412-2. Epub 2008 Oct 9.
9
Small molecule inhibitors of protein interaction with glycosaminoglycans (SMIGs), a novel class of bioactive agents with anti-inflammatory properties.与糖胺聚糖相互作用的蛋白质小分子抑制剂(SMIGs),一类具有抗炎特性的新型生物活性剂。
Biochim Biophys Acta. 2014 Jan;1840(1):245-54. doi: 10.1016/j.bbagen.2013.09.023. Epub 2013 Sep 21.
10
Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin.肝素硫酸酯基团调节荷兰突变型 Abeta40(DAbeta(1-40))对培养的脑血管细胞的聚集和细胞毒性。
Neurosci Res. 2010 Apr;66(4):380-9. doi: 10.1016/j.neures.2009.12.012. Epub 2009 Dec 30.

引用本文的文献

1
Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges.蛋白聚糖如何决定趋化因子-CXCR1/CXCR2 相互作用的结构见解:进展与挑战。
Front Immunol. 2020 Apr 24;11:660. doi: 10.3389/fimmu.2020.00660. eCollection 2020.
2
Structure-based engineering of heparinase I with improved specific activity for degrading heparin.基于结构的肝素酶 I 工程改造,提高了肝素降解的比活性。
BMC Biotechnol. 2019 Aug 9;19(1):59. doi: 10.1186/s12896-019-0553-3.

本文引用的文献

1
Cross-Species Analysis of Glycosaminoglycan Binding Proteins Reveals Some Animal Models Are "More Equal" than Others.跨物种糖胺聚糖结合蛋白分析揭示了一些动物模型比其他模型更“平等”。
Molecules. 2019 Mar 6;24(5):924. doi: 10.3390/molecules24050924.
2
Structural Features of Heparan Sulfate from Multiple Osteochondromas and Chondrosarcomas.多种骨软骨瘤和软骨肉瘤中硫酸乙酰肝素的结构特征。
Molecules. 2018 Dec 11;23(12):3277. doi: 10.3390/molecules23123277.
3
Solution Conformation of Heparin Tetrasaccharide. DFT Analysis of Structure and Spin⁻Spin Coupling Constants.
肝素四糖的溶液构象。结构和自旋-自旋耦合常数的 DFT 分析。
Molecules. 2018 Nov 21;23(11):3042. doi: 10.3390/molecules23113042.
4
The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard.肝素酶酶活性检测方法的发展:迈向金标准。
Molecules. 2018 Nov 14;23(11):2971. doi: 10.3390/molecules23112971.
5
Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity.硫酸乙酰肝素模拟物在癌症治疗中的应用:定义结构决定因素和目标相关性的挑战,以实现最佳活性。
Molecules. 2018 Nov 8;23(11):2915. doi: 10.3390/molecules23112915.
6
The Pro-Tumoral Activity of Heparan Sulfate 3--Sulfotransferase 3B (HS3ST3B) in Breast Cancer MDA-MB-231 Cells Is Dependent on the Expression of Neuropilin-1.肝素硫酸 3--硫酸转移酶 3B(HS3ST3B)在乳腺癌 MDA-MB-231 细胞中的促肿瘤活性依赖于神经纤毛蛋白-1 的表达。
Molecules. 2018 Oct 22;23(10):2718. doi: 10.3390/molecules23102718.
7
The Low Molecular Weight Heparin Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways.低分子量肝素亭扎肝素通过凝血依赖性和非依赖性途径减弱转移龛形成中的血小板活化。
Molecules. 2018 Oct 24;23(11):2753. doi: 10.3390/molecules23112753.
8
Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.未分级肝素和低分子量肝素可降低胰腺癌细胞和前列腺癌细胞中的血小板诱导的上皮间质转化。
Molecules. 2018 Oct 19;23(10):2690. doi: 10.3390/molecules23102690.
9
Low-Molecular-Weight Heparins: Reduced Size Particulate Systems for Improved Therapeutic Outcomes.低分子肝素:用于改善治疗效果的小粒径颗粒系统。
Molecules. 2018 Jul 18;23(7):1757. doi: 10.3390/molecules23071757.
10
Chemoenzymatic synthesis of heparan sulfate and heparin oligosaccharides and NMR analysis: paving the way to a diverse library for glycobiologists.硫酸乙酰肝素和肝素寡糖的化学酶法合成及核磁共振分析:为糖生物学家打造多样化文库铺平道路。
Chem Sci. 2017 Dec 1;8(12):7932-7940. doi: 10.1039/c7sc03541a. Epub 2017 Sep 21.