Krachmer J H, Purcell J J, Young C W, Bucher K D
Arch Ophthalmol. 1978 Nov;96(11):2036-9. doi: 10.1001/archopht.1978.03910060424004.
A prospective study was undertaken during an 18-month period with 64 families who had endothelial dystrophy. Two hundred twenty-eight relatives were examined. Of those older than the age of 40, 38% were affected. Women were affected more severely and 2.5 times more frequently than men. The disease showed a strong familial tendency: there was one family in which three generations were affected and 16 families in which two generations were affected. There were four families that had members with edema in two generations. There was no association between edema in a parent and edema in a child. The proportion of relatives affected and the severity of involvement increased with age. Fifty-three probands and 18 relatives had endothelial dystrophy with edema (Fuchs' dystrophy). Of these 71, one had glaucoma.
在18个月期间对64个患有内皮营养不良的家庭进行了一项前瞻性研究。检查了228名亲属。在40岁以上的亲属中，38%受到影响。女性受影响更严重，频率是男性的2.5倍。该疾病显示出强烈的家族倾向：有一个家庭三代人受影响，16个家庭两代人受影响。有4个家庭两代成员有水肿。父母的水肿与孩子的水肿之间没有关联。受影响亲属的比例和受累严重程度随年龄增加。53名先证者和18名亲属患有伴有水肿的内皮营养不良（富克斯营养不良）。在这71人中，1人患有青光眼。
